Awareness Drive -- Glutathione and its link to many diseases.

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What Everyone Needs to Know About Glutathione

Back in 1747, James Lind's discovery that Vitamin 'C' could cure scurvy was a major medical breakthrough, that saved countless lives.

Since then, Vitamin C has been found to be beneficial for many other things as well. However, it wasn't until 1954 that scientists began to understand exactly why it's so powerful. During that year, a researcher named Dr. Denham Harman formulated the free radical theory of aging. This theory suggested that aging is actually caused by free radicals, which attack and damage the cells of the body. Dr. Harman further theorized that this process could be slowed by antioxidants, nutrients with the power to neutralize free radicals and heal the cellular damage caused by them.

Other scientists at first scoffed at Dr. Harman's idea; however, it has since been proven by numerous studies. It is now known that Vitamin C is an antioxidant and that is why it has so many benefits.

In recent decades, however, researchers have discovered an antioxidant that is even more powerful. It is known as Glutathione, and it is present in every cell of the body.

WHAT IS GLUTATHIONE?

Glutathione is produced naturally in the liver. It is made up of three amino acids, and it is vital for cellular metabolism. It protects against oxidative stress caused by free radicals, is required for the immune system to function properly, and is a potent detoxifier.

The importance of glutathione has been validated by over 92,000 scientific articles, more than twice the amount that has ever been published about vitamin C. In fact, nutrition experts believe that it is just as necessary for our health as oxygen, food and water.





WHY DO WE NEED GLUTATHIONE?

Glutathione helps other antioxidants and nutrients do their jobs properly. Without it, no amount of supplementation or healthy eating will do us any good. In addition, since our immune system depends on this substance, a lack of it causes us to get sick more often. It also protects our mitochondria, which provide energy to our cells. Our mitochondria are very vulnerable to the effects of free radicals, so if glutathione weren't present they would deteriorate very quickly and our cells would die.

Furthermore, this antioxidant helps our body get rid of toxins. This is important, because most of us are exposed to dangerous chemicals on a daily basis. In fact, a study by Cornell University found that over 60% of the world's population is harmed by air pollution, and the Institute of Occupational Safety and Health recently found that almost 900 of the chemicals used in cosmetics and skincare products are toxic.

Although glutathione is produced naturally in the body, its levels begin to decline at around twenty years of age. From that point, they decrease by 8% to 12% every decade.

By the time a person is 50, these levels are only at 60% to 70% of what they were in their teens.

The level of glutathione in our body is also lowered by sickness, toxins and other things that cause physical or emotional stress. Because it is nearly impossible to avoid these things with our modern lifestyle, most people do not have enough glutathione in their bodies.

Glutathione has been widely studied with over 99,000 published peer-reviewed scientific papers on this topic. In one review, almost 80% of people with chronic ailments were found to be deficient in glutathione. In fact, low levels of glutathione are involved in all disease states. The following symptoms, diseases and illnesses have been linked to low glutathione levels. (To find the scientific papers that have been published on each of these topics in relation to glutathione, visit www.pubmed.gov and type in “glutathione” and the symptom/disease/illness/syndrome of interest).



More...

Glutathione is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and a detoxifier and is a major defense system against illness and aging. Our glutathione level indicates our state of health and can predict longevity. Although there are more than 99,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.



Increasing intracellular glutathione levels has been shown to:

dramatically increase energy levels;
strengthen the immune system;
aids cell detoxification;
chelate heavy metals like mercury (i.e., bind to heavy metals, so that they can be removed from the body);
fights off the damage of free radicals on the cells;
slow down the aging process;
reduce inflammation or swelling;
improve athletic performance and recovery;
detoxify and improve liver function;
increase stamina and endurance;
improve memory and other mental functions;
improve vision;
improve heart and lung function;
aids muscle and joint recovery;
mood improvement;
improves quality of sleep;
improves the health of skin and decreases wrinkles;
eases anxiety; and
protects from degenerative diseases and reduces the chances of developing cancer

“Glutathione levels go down in every age group except one and that one are the people who reach a hundred years of age. Those people, interestingly, have glutathione levels that approximate those of a normal 30 to 40 year old.”
- Dr. Robert Keller

Glutathione levels decrease as a result of:

aging (glutathione levels decrease by 10-15% every decade);
stress;
inflammation;
sun exposure;
athletic activities;
sleep deprivation; and
environmental toxins.



How do you increase glutathione levels?

Increasing intracellular glutathione levels is typically a complicated process. Glutathione can be taken intravenously, transdermally or through a nebulizer. Note that supplementing directly with oral glutathione is generally not effective because studies have found that glutathione does not survive the digestive process. Furthermore, supplementing with oral glutathione can result in a yeast outbreak and gut imbalance. Injections are only minimally useful, since glutathione cannot enter into the cells themselves. It must be manufactured inside the cells (when the necessary components are available.) As Dr. Kartzinel explains, methyl B12 injections and supplementing with trimethylglycine (TMG) or dimethylglycine (DMG), folic acid and N-acetyl-cysteine can increase glutathione levels.



Check this long list of diseases associated with low glutathione levels and its scientific papers published in pubmed.

Health Concerns and Low Glutathione Levels « Healing with Glutathione

Name a particular disease and its highly likely due to glutathione deficiency. here's what experts have to say about glutathione



and this...





best explaination why low glutathione levels are directly linked to diseases and illnesses

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Antioxidants101: Endogenous Vs Exogenous Antioxidant



Free radicals - are highly reactive, unstable molecules that have lost one electron and are aggressively looking for a replacement. Free radicals are formed in the body, and its production is increased when we are exposed to such things as tobacco smoke, alcohol, insecticides, radiation and even to sunlight. Other causes are a high-fat diet, eating fried foods, or strenuous exercise. It is the free radical production from these sources that we need to be most concerned about. In a simple explanation, FREE RADICALS are responsible to cell damage.

Exogenous Antioxidant - antioxidant that we obtain from our diet and supplements. Vitamin C and Vitamin E are the most popular exogenous antioxidant that floods the market.

Endogenous Antioxidant - antioxidant produced by our body. More powerful free radical fighter than those you can get from your diet. The five important endogenous antioxidants are Superoxide Dismutase (SOD). Glutathione, Alpha Lipoic Acid (ALA), Catalase and Coenzyme Q10 (CoQ10).

Our body produces more SOD, Catalase and Glutathione when certain free radicals are present. It is our body's Frontline defense (First Line of Defense).

Important Roles of Endogenous Antioxidant:

> SOD can convert the most reactive or most dangerous free radicals into hydrogen peroxide, which catalase and Glutathione can then turn into oxygen and water, neutralizing them.
> ALA, Glutathione and CoQ10 has properties that can regenerate and recycle some exogenous antioxidants. **Example - Vitamin C (Ascorbate) donates an electron to a free radical to neutralize it, making it dehydroascorbate which has a half-life in the body of only a few minutes. If the dehydroascorbate is not rereduced (given back its lost electrons) back to ascorbate, it is irreversibly lost making it a weak free radical. Endogenous antioxidants can regenerate this dyhydroascorbate, turning it back to ascorbate form so it can combat another free radical again.

What Makes Glutathione Stand Out from other Endogenous Antioxidant?
Glutathione is present in each and every cell of our body, found in high concentrations in liver cells. It is the cell’s primary antioxidant against free radicals produced by toxic chemicals and viruses. Glutathione also plays an essential role in the liver’s detoxification process (Phase II system).
Glutathione has the ability to repair DNA damage caused by free radicals at the cellular level, it plays a role in boosting the immune system and in slowing down the natural ageing process.... Glutathione indeed is the Most Important and Most Powerful Antioxidant inside our body.

How Powerful is Glutathione?
Antioxidant donates electron to free radicals to neutralize it. Let's make an example how many free radicals some popular antioxidants can neutralize:
> Vitamin E - a molecule of vit.E has 3 electrons to share, meaning it can neutralize 3 free radicals at a time.
> Vitamin C - has 2 to 5 electrons to share, means it can neutralize 2 to 5 free radicals at a time.
> Glutathione - has 1 million electrons to share, it can neutralize 1million free radicals at a time as well as give back the lost electrons of exogenous antioxidants like vitamin c and vitamin e making them functional again.
It is estimated that every one of the cells in our body receives 10,000 hits a day from free radicals, assuming we have 50 to 75 trillion cells, imagine the total hits from free radicals we encounter per day! If we will rely from exogenous antioxidants to neutralize that many free radicals, we would have to consume approximate amount of 375 oranges or 87 glasses of red wine or 120 vitamin C capsule! Glutathione being our body's frontline defense, do most of the work in neutralizing these free radicals.

Important Facts:
> Endogenous and Exogenous Antioxidants, revive and spare one another from destruction. So those exogenous antioxidants coming from our diet and supplements are also important.
> Taking Vitamin C and Vitamin E and other exogenous antioxidant supplement is also needed if we need to give our body a boost by helping and aiding glutathione.
> It is evident that we need to rely on replenishing glutathione at the cellular level to be healthier and live longer.
> When we are Younger, our body is capable of producing enough endogenous antioxidants to combat free radicals on their own. Capability decreases as we age, making us vulnerable to sickness.

For decades, the main problem encountered with glutathione sold as a supplement is that only very small amounts can be absorbed into the blood stream because of its large molecule size aside from our body breaks them down in the process of digestion.



Scientific Breakthrough:
Dr. Robert H. Keller has formulated a cost effective way to promote glutathione production at the cellular level. This Genius formulated a “Glutathione Accelerator”. To know more about this scientific breakthrough, click HERE

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Don't flush your money out by taking oral glutathione. IV glutathione is also not recommended.

Food and Drug Administration - Warning To The Public
http://www.fda.gov.ph/Advisory/Advis...202011-004.pdf

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Glutathione Deficiency

What causes Glutathione deficiency?
Your Glutathione Levels are Falling whether you like it or not. Glutathione levels diminish as we age. Your body's natural glutathione production begins to decline by 10% to 15% per decade starting at the age of 20. Glutathione deficiency is alarming because all other antioxidants rely on the presence of glutathione to function and do their job properly. This is the main reason that as we age (hence glutathione levels become lower) we become prone to illnesses.

"Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases." Glutathione: Essential Health AID - Antioxidant, Immune Booster... Dr. Jimmy Gutman, MD, FACEP.

Diseases Associated with Decreased (Low) Levels of Glutathione

GENERAL
Obesity, Immune Signaling, Endothelial dysfunction, Alcoholism,
Inflammation. Heavy metal poisoning.

CARDIOVASCULAR
Angina and spastic angina, Unstable angina, Heart attacks, Positive
stress tests, Reperfusion after cardiac bypass surgery, hypertension

PULMONARY
Emphysema (COPD), Pulmonary fibrosis (IPF), Asthma, Muscle wasting
in COPD, Chronic bronchitis, Tobacco abuse

NEURO/PSYCH
Migraine headaches, Alzheimer's, Parkinson's, Multi infarct dementia,Autism, ADHD (Attention Deficit Hyperactivity Disorder), Bipolar disease, Schizophrenia, Lou Gehrig's disease, Huntington's chorea, Multiple Sclerosis, Depression

INFECTIOUS DISEASES/IMMUNOLOGY
Hepatatis A, B, and C, Herpes Simplex, Herpes Zoster/Shingles, Influenza and Bird Flu, HIV, MRSA, Common viral infections (upper respiratory, gastroenteritis), others.

RHEUMATOLOGY
Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis, Systemic Sclerosis (Scleroderma) Syndrome, Behcet's Syndrome, ME/CFS, Fibromyalgia, others.

DERMATOLOGY
Wrinkles (sagging), Acne, Psoriasis, Atopic Dermatitis, Eczema, Others.

ONCOLOGY
Every Cancer studied including Brain cancer, Head and Neck cancer, Thyroid/Lung/Esophagus/Stomach cancer, Intestine cancer, Liver cancer, Pancreas/Kidney/Uterine/Ovarian Cancer, Prostate Cancer, Leukemia (acute and chronic), Lymphoma, Multiple myeloma, others.

OB/GYN
Infertility, Spontaneous abortions, Pre Menstrual Syndrome

OPTHAMOLOGY
Cataracts, Macular Degeneration

Correction of Glutathione Deficiency
Studies have demonstrated that oral glutathione is not well absorbed by many of the mammal's cells and does not replenish losses inside cells where it is most needed.

[prestige]

Have you read this dude?

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Diabetes and Glutathione

What is Diabetes?
A disorder of glucose or blood sugar metabolism. The body is not capable of breaking down glucose in the blood stream.

Major Types of Diabetes
Type 1 diabetes - the body is unable to produce insulin that is needed to break down blood glucose so the body may use it.
Type 2 diabetes - the common type of diabetes where the body has the ability to produce the needed insulin, but it cannot be recognized by the cells. The major cause of type 2 diabetes is obesity.

Diabetes Symptoms
Studies indicate that early detection of diabetes symptoms and treatment may lower the chance of having diabetes complication. Diabetes often goes undiagnosed because many of its symptoms are harmless.

Type 1 Diabetes Symptoms
Frequent urination
Unusual thirst
Extreme hunger
Unusual weight loss
Extreme fatigue and Irritability

Type 2 Diabetes Symptoms
Any of the type 1 symptoms
Frequent infections
Blurred vision
Cuts/bruises that are slow to heal
Tingling/numbness in the hands/feet
Recurring skin, gum, or bladder infections
Note: some people with type 2 diabetes have no symptoms

How can we control or treat Diabetes?
Regular exercise and Healthy diet is essential, foods high in fiber, nuts, onions and garlic are a good food choice to control blood glucose at a safe level. Apart from diet and exercise, antioxidant supplement is also needed. Exogenous Antioxidants that we get from food we eat is not enough if you have diabetes because your body is compromised and may not have the ability to use it efficiently. We need the help of Endogenous antioxidants to overcome diabetes naturally.

Based on research, diabetics have high level of oxidative stress and low levels of natural glutathione gsh. Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with diabetes. Complications will arise under these circumstances; the most common is heart disease, for people suffering from diabetes.

It is recommended for diabetics to increase their natural glutathione level. Glutathione, being the most prevalent endogenous antioxidant, can neutralize oxidative stress or free radicals. It also has the ability to repair damaged cells, which will result to healthy tissues and healthy organs.

How to increase Glutathione Level?
You can use glutathione accelerator or supplements that can give your body the nutrients needed so that your cells can manufacture it at the cellular level.

How to Regulate or Control Blood Sugar Level
Antidiabetics maintenance medicine for those with diabetes might be needed, but utmost care should be made. It can deplete you of essential nutrients needed by your body.

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Psoriasis and Glutathione

What is Psoriasis?
Psoriasis is an autoimmune disease that appears on the skin. It occurs when the immune system mistakes the skin cells as a pathogen, and sends out faulty signals that speed up the growth cycle of skin cells. The most common form, plaque psoriasis, is commonly seen as red and white hues of scaly patches appearing on the top first layer of the epidermis.

Individuals with psoriasis are at an elevated risk to develop other chronic and serious health conditions also known as "comorbid diseases" or "comorbidities.” These include heart disease, inflammatory bowel disease and diabetes. People with more severe cases of psoriasis have an increased incidence of psoriatic arthritis, cardiovascular disease, hypertension., diabetes, cancer, depression, obesity, and other immune-related conditions such as Crohn's disease.

While others are struggling to treat and cure Psoriasis, we found out that with increasing Endogenous Antioxidant Glutathione at the cellular level, Psoriasis will never be a Problem anymore! For best results, take Glutathione Accelerator.

Below are the Symptoms and some facts about Psoriasis:
• It is not a contagious disorder.
• Psoriasis is manifested by silvery, scaly patches that commonly appear on the scalp, ears, arms, legs, knees, elbows and back.
• Skin cells are produced quickly, skin cells were replaced for only 2 to 6 days instead of the normal 21 to 28 days period.
• Psoriasis affects around 3% of people globally.
• Usually affects patients between age 11 to 45.
• Constant shedding of dead skin cells.
• Both dead and live cells accumulate on the skin surface.
• There is a genetic link and it tends to run in families. About 30% of people with one first degree relative with psoriasis develop the condition.
• There is no way of predicting who will develop psoriasis.
• 50-60% of people who first experience it do not know of anyone else in their family who has had it.
• Patients with Psoriasis have low levels of Glutathione or
suffering from Glutathione Deficiency.

The exact cause of psoriasis is still not known, but certain things act as triggers, and set the stage for a flare-up. Among them are food allergies, nutritional deficiencies, climate changes, damage to the skin
from dryness, local injury or sunburn, reaction to certain drugs, infections, build up of toxins in an unhealthy colon and emotional stress.

Aside from increasing Glutathione at the cellular level, taking exogenous antioxidant and Vitamin B complex that makes skin healthy might help. Natural Glutathione inhibit the growth of psoriatic cells, it
may also bring the cells back to its normal condition by making the DNA healthy. Detoxification programs are also helpful for patients with psoriasis to get rid of potential triggering toxins.

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How do you know if you need to increase you Glutathione levels?

Most serious chronic diseases are linked to low levels of Glutathione. If you suffer from diabetes, cancer, arthritis or serious infection, it may indicate that you are depleting your Glutathione. Take into account your general health, if you feel chronically fatigued and run down your levels of Glutathione may be low.

Glutathione is responsible for eliminating the oxidants that are created as a byproduct of the production of ATP in your cells. If there is not sufficient availability of Glutathione in your body to eliminate these oxidants that are constantly being produced by your cells, then your cells become unable to generate energy at full potential. Additionally, you wind up with elevated amounts of oxidants in your body. The medical literature supports the fact that too many oxidants in your body, coupled with a lack of sufficient levels of antioxidants (Glutathione) to eliminate them, can result in accelerated cellular aging.

What effects have been seen by increasing Glutathione levels?

Dr. Keller’s work in his private practice saw numerous patients, of all varying aliments, benefit from increasing Glutathione levels. Medical research is consistently identifying cause and effects of Glutathione. For example, can a Glutathione Precursor slow the progression of Parkinson’s disease?

Oral supplementation with the Glutathione (GSH) precursor (N-acetylcysteine (NAC)) slowed the progression of brain cell death in a mouse model of Parkinson’s disease (PD). The mice have lower levels of GSH within the brain due to impaired uptake of cysteine. Over time, these mice develop brain damage similar to that observed in Parkinson’s disease. Provision of NAC within the drinking water had profound effects on the level of GSH and brain damage observed within the brains of aged mice and represents an option for the future treatment of Parkinson’s disease.

This report was the result of funding received by the Michael J Fox Foundation for Parkinson’s Research. Follow this link to read the entire text of published abstract on this study: N-acetylcysteine prevents loss of dopaminergic ne... [Ann Neurol. 2011] - PubMed - NCBI

How can you increase Glutathione levels?

You can increase the production of Glutathione with daily supplementation, proper dieting and exercise. Boosting Glutathione levels effectively will purge your body of toxins and result in a healthier immune system.

Eating sulfur-rich vegetables, such as broccoli, cauliflower, garlic and onions
Eating selenium-rich foods, such as oats, black beans, tuna and brazil nuts
Daily Supplementation with glutathione accelerator (not glutathione supplements)
Regular moderate exercise

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if you are still in doubt about these claims, you can do more research... but this genius already did



Dr. Robert H. Keller, MD, MS, FACP, was a triple board certified physician and research scientist. A brilliant scholar, Dr. Keller had a distinguished academic career and highly acclaimed researcher of Gutathione.

Dr. Rob Keller had served on the scientific review panels for the National Institutes of Health and the United States Department of Veterans Affairs. Dr. Keller was a faculty member of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.).

Notable Honors & Awards:

Named one of the world’s 2,000 Outstanding Scientists of the 21st Century
Elected to The Board of Governors of the American Academy of HIV Medicine
Recognized as one of America’s “Top Physicians in 2003, 2004, 2005, 2006, and 2007 in the fields of Internal Medicine, Immunology and Hematology
Humanitarian of the Year award by the National Hemophilia Foundation in 1999
Featured in the “Guide to America’s Top Physicians”


Dr. Robert H. Keller published more than 100 original articles in various scientific and medical journals and was awarded several patents. He wrote a book, GLUTATHIONE Your Best Defense Against Aging, Cellular Damage and Disease. This in-depth monograph explains why Glutathione is the most powerful and life-sustaining antioxidant in the human body.

Dr. Keller passed away in 2009; He is remembered as an exceptional scientist, compassionate physician and an accomplished educator. Thousands continue to attribute their improved health and vitality to the discoveries and patented formulations of Rob Keller MD. This is the Curriculum Vitae of Dr. Robert Keller, as of the date of his untimely passing.



...and don't miss this lecture he had years ago after researching glutathione from pubmed




Increase your body's natural production of glutathione by taking glutathione accelerator. Taking whole glutathione supplements are deemed useless since it will be broken down as it passess the gastrointestinal tract. Injectables (IV) are also less effective because the glutathione molecule is too big to pass the cell membrane.