Yes you can. This really is not the best example but here is a photo example:

EXIF
Exposure: 20 seconds
Aperture: f/8.0
Focal Length: 17 mm
ISO Speed: 100
A CPL, ND106, and 2-stop GND was used here. The ND106 allowed me to get a 20 second exposure to produce a cloud-like effect on the water. GND helped lift the shadows off the foreground and allows me to get an even exposure of the foreground and sky. The CPL enhances colors and somewhat reduces glare from the wet rocks.
The only downside to stacking filters is vignetting on a wide angle lens. That's when darkening on the corners occur. To avoid this, I only shoot at 12mm or higher on the Canon 10-22.